Therapeutic Plasma Exchange operates on a surprisingly simple yet powerful principle: rather than trying to add beneficial factors to combat aging, TPE focuses on removing the harmful substances that accumulate in our blood plasma over time.
During the procedure, your blood is drawn through an IV line and passed through a sophisticated centrifugal separation system that isolates the plasma (the liquid portion of blood) from your red blood cells, white blood cells, and platelets.
The aged plasma, which contains elevated levels of inflammatory proteins, autoantibodies, and cellular damage signals, is then discarded and replaced with fresh albumin and saline solution before the refreshed blood is returned to your circulation.
The therapeutic power of TPE lies in its ability to address aging at the systemic level by removing what researchers call "age-imposed systemic molecular excess."
As we age, our tissues increasingly secrete inflammatory mediators, growth inhibitors, and cellular damage signals into our bloodstream, creating an environment that impairs regenerative capacity across multiple organ systems. By diluting these harmful factors through plasma replacement, TPE effectively recalibrates the entire circulatory environment to a more youthful state.
Patient's blood is drawn through IV access and anticoagulated to prevent clotting
Centrifugal separation removes aged plasma containing harmful inflammatory factors
Fresh albumin & saline solution replace the removed aged plasma
Refreshed blood returns to circulation, promoting cellular repair and regeneration
Think of your body as a sophisticated biological machine that, over time, accumulates cellular "rust" and systemic "wear" that gradually impairs its performance.
Therapeutic Plasma Exchange acts like a comprehensive system reset, addressing multiple aging mechanisms simultaneously to restore more youthful function. By removing age-elevated inflammatory proteins and damage signals from your circulation,
TPE reduces oxidative DNA damage, decreases cellular senescence markers, and eliminates the molecular "noise" that interferes with proper cellular communication. This systemic cleansing reactivates dormant stem cells, normalizes critical signaling pathways and restores immune system balance.
The result is a global shift toward a younger systemic proteome that enhances tissue repair capacity across multiple organ systems - essentially giving your biological machine the deep maintenance it needs to run more like its younger self, with measurable improvements in muscle regeneration, brain function and overall cellular vitality.
TPE reduces oxidative DNA damage markers and decreases expression of senescence indicators like p16, restoring cellular genomic integrity.
Eliminates age-elevated inflammatory mediators (IL-6, TNF-α) that accumulate with aging and impair tissue regeneration capacity.
Improves lymphoid to myeloid cell ratios and enhances immune function, creating a more youthful systemic immune environment.
Normalizes critical aging pathways including JAK-STAT, MAPK, TGF-beta, and NF-κB to restore youthful cellular communication.
Removes growth inhibitors and cellular damage signals, reactivating resident stem cells for enhanced tissue repair and regeneration.
Creates a global shift toward a younger systemic proteome, including restoration of pro-regenerative and anti-cancer regulators.
Removes senescence-associated secretory factors that cause neighboring cells to age, promoting tissue-wide rejuvenation.
Improves cellular energy production and metabolic efficiency by removing metabolic inhibitors and oxidative stress factors.
Dr. Dobri Kiprov, our Consulting Physician is a leading immunologist and neurologist in the field of Therapeutic Plasma Exchange.
His research has led the field in these emerging medical treatments.
Dr Kiprov is an immunologist and internationally recognized leader in apheresis, with over 100 publications on the subject. He is pioneering the use of TPE to mitigate the effects of aging and has conducted several controlled and uncontrolled studies.
Dr Kiprov founded Global Apheresis and co-founded Lyfspan, a company devoted to aging research in the United States. He is also a senior visiting scientist at the Buck Institute for the Research of Aging.
He has served two terms on the American Society for Apheresis Board of Directors and is currently a member of the International Society of Apheresis Board of Directors. He is also a Journal of Transfusion and Apheresis Science editorial board member.
Following is some of the research that supports the clinical aspects of the treatments provided at MyLongevity.
Watch this YouTube video as Dr Kiprov explains the process and benefits of TPE and what it is doing for longevity research.
Kim et al., 2022: "Old plasma dilution reduces human biological age: a clinical study" - GeroScience, demonstrating measurable biological age reduction through TPE.
Fuentealba et al., 2024: "Multi-omics analysis reveals biomarkers that contribute to biological age rejuvenation" - Aging Cell, showing 2.61-year biological age reduction with TPE+IVIG.
Mehdipour et al., 2020: "Rejuvenation of three germ layers tissues by exchanging old blood plasma" - Aging, demonstrating tissue rejuvenation across multiple organ systems.
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